What Is the Skinny on Neurotoxins?

What Is the Skinny on Neurotoxins

Neurotoxin use is a controversial topic even among those who use the cosmetic—some celebrities like Cindy Crawford state that her skin quality is due to her cosmetic surgeon and Botox. Robin Wright says one unit of Botox sprinkled here and there takes the edge off, but she does not say for sure if she uses neurotoxins. British actor Olivia Coleman absolutely loves Botox. She uses it when she has a gap between roles. Sharon Osbourne loves Botox. She admits that she has received the cosmetic treatment and says it is “one of the best things that have ever been created for cosmetic surgery.” (https://www.marieclaire.com/beauty/news/g4289/celebrities-who-have-spoken-about-botox/).

Expression lines are evidence of a happy life and all the times you smiled and laughed in your life. However, you may not want those memories etched on your face and would like to remember happy times but not see them on your face. If you have expression wrinkles like crow’s feet, forehead lines, and furrows between your brows, neuromodulators can help. Neurotoxins are great for smoothing and diminishing wrinkles and lines and preventing the increased intensity of aging lines.

Neurotoxins can prevent fine lines and wrinkles, but it is more difficult to smooth their appearance if you wait until those lines are etched into your skin. Use neurotoxins preventatively or before your expression lines are set, and your muscles will learn not to make certain expressions. In addition, the measures you take today will cause you to need fewer neurotoxins and less often.

How do Neurotoxins work?

There are four main neurotoxins used for cosmetic purposes, and these differences exist in the manufacturing and formulation of neurotoxins. All neurotoxin formulations cause muscular temporary immobilization by preventing acetylcholine (ACh) from releasing into the muscle’s nerve endings. Stopping ACh release stops the muscle movement from forming wrinkles.

The toxin molecule blocks the connection between the nerves and the muscles within one minute of injection. You will see results from your treatments in about seven days, and the full impact will be seen in about 10-14 days. You will need to repeat neurotoxin injections every 3-4 months.

Injecting the botulinum toxin temporarily inhibits the nerve cells that signal certain muscles to contract. As a result, it helps to decrease facial movements that cause fine lines and wrinkles. Once these expression muscles are weakened, you can still make expressions, but they are less exaggerated.

Your body will naturally metabolize the product and begin to break it down over time. As communications come back to the muscles, lines and wrinkles that were originally there on your face will reappear. However, studies have shown that each use of neurotoxins will actually last longer and longer.

What are the Four Major Formulations of Neurotoxins?

Wrinkle smoothing botulinum toxin Type A is the most non-invasive aesthetic procedure to diminish wrinkles. Colloquially, they are all called “Botox,” but there are four different injectables FDA approved for cosmetic use.

These neurotoxins have the same basic chemical in common, yet they are unique. All the neurotoxins take a similar amount of time and produce comparable

results. But if you compare one brand of neurotoxin to another, it is almost

like comparing apples to apples. For example, apples are applied, but there is a difference between Granny Smith apples and Jonathan apples.

Different manufacturers make the four injectables, and these different manufacturing techniques lead to different costs, potencies, and formulations. The active ingredient is botulinum toxin type A, but some may have protein blends affecting diffusion and efficacy.


In 2002, the FDA first approved Botox as an aesthetic treatment to improve the appearance of frown lines between the eyebrows. Since 2002, Botox has been FDA cleared to diminish crow’s feet and forehead lines. The product also has many off-label uses that help reduce migraines, excessive sweating, lazy eye, neck spasms, and an overactive bladder.


The FDA approved Dysport in 2009 to treat moderate to severe frown lines between the eyebrows. Ipsen manufactures Dysport under a partnership with Galderma. Dysport is formulated with human albumin, lactose, and cow’s milk protein. You cannot use Dysport if you have milk allergies. In addition, Dysport’s effects may show up sooner than Botox, which is a thinner preparation.


Jeuveau was FDA approved in 2019. Evolus makes Jeuveau and includes human albumin plus sodium chloride in their formula. Jeuveau offers the same benefits as Botox but costs about 20 to 30 percent less than Botox.


The FDA approved Xeoman for treating frown lines in July 2011. It has also been approved to correct muscle spasticity and excessive drooling. The company Merz makes Xeomin, and it does not blend BoNT-A with other proteins. As a result, this neurotoxin does not need to be refrigerated, and fewer units are needed to achieve the desired result. Results from Xeomin take five to seven days and last about the same amount of time as the other three neurotoxins.

You have a choice of Botox or Dysport at The Spa on Highland. The professionals at the medspa will sit down and discuss Botox and Dysport and let you know which one is best for you. Set up a consultation at The Spa on Highland Sandy, UT, at https://thespaonhighland.com or call them at 801-943-3260.


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